Methotrexate: clinical and immunological effects in refractory rheumatoid arthritis.
Article
Dans Anglais
| IMSEAR
| ID: sea-90474
ABSTRACT
Thirty five patients with refractory rheumatoid arthritis were given 7.5 mg of methotrexate (Mtx) every week. Eleven patients had to discontinue treatment either because of adverse effects or unresponsiveness. Twenty four patients showed clinical response and significant improvement in ESR and they continued Mtx for a mean of 25.24 months. Seven patients achieved clinical remission as defined by ARA criteria. Immunological parameeters including IgG, IgM, IgA, lymphocyte subsets (CD3+, CD4+, CD8+ and B), C3 and C4 however, did not show any change during this treatment in any of the groups upto 6 months. There was a significant fall in the erythrocyte sedimentation rate (ESR), c-reactive protein (CRP) and rheumatoid factor (RF) levels in responders only.
Texte intégral:
Disponible
Indice:
IMSEAR (Asie du Sud-Est)
Sujet Principal:
Polyarthrite rhumatoïde
/
Vomissement
/
Sédimentation du sang
/
Induction de rémission
/
Femelle
/
Humains
/
Mâle
/
Méthotrexate
/
Administration par voie orale
/
Études prospectives
Type d'étude:
Étude observationnelle
/
Étude pronostique
langue:
Anglais
Année:
1992
Type:
Article
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