Hematopoietic growth factors in drug-induced agranulocytosis.
Article
Dans Anglais
| IMSEAR
| ID: sea-90702
ABSTRACT
Drug-induced agranulocytosis (DIA) is a potentially fatal disorder. Hematopoietic growth factors have been used in the treatment of DIA. We report nine cases of DIA treated with granulocyte macrophage - colony stimulating factor (GM-CSF) in a dose of 300 microg/day. All the patients had evidence of systemic infection. Mean time to reach an absolute neutrophil count of 0.5 x 10(9)/L was three days. One patient succumbed to the disease. The cause of death was multiorgan failure. No adverse events were observed with GM-CSF. We conclude that hematopoietic growth factors are useful in shortening the period of neutropenia and reducing morbidity and mortality in these patients.
Texte intégral:
Disponible
Indice:
IMSEAR (Asie du Sud-Est)
Sujet Principal:
Sulfasalazine
/
Femelle
/
Humains
/
Mâle
/
Chlorpromazine
/
Métamizole sodique
/
Études rétrospectives
/
Facteur de stimulation des colonies de granulocytes et de macrophages
/
Adolescent
/
Résultat thérapeutique
Type d'étude:
Étude observationnelle
langue:
Anglais
Année:
2002
Type:
Article
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