Angiotensin-II behaves as an endogenous pro-inflammatory molecule.
Article
Dans Anglais
| IMSEAR
| ID: sea-93647
ABSTRACT
Angiotensin-II regulates vascular tone, stimulates the release of pro-inflammatory cytokines, activates NF-kappaB, increases oxidant stress, and suppresses nitric oxide synthesis, and thus, it functions as an inflammatory molecule. Since ACE is present in many tissues, this suggests that angiotensin-II may play a significant role in atherosclerosis, congestive cardiac failure, stroke, bipolar disorder, schizophrenia, dementia, Alzheimer's disease, psoriasis, atopic and non-atopic dermatitis, eczema, several acute and chronic inflammatory diseases, and cancer, conditions in which inflammation is an aetiopathogenic factor. Thus, ACE inhibitors and/or angiotensin-II receptor blockers could be of benefit in these conditions. Furthermore, structural analogues of ACE inhibitors and angiotensin-II receptor blockers could be developed that possess anti-inflammatory actions without significant action on the cardiovascular system.
Texte intégral:
Disponible
Indice:
IMSEAR (Asie du Sud-Est)
Sujet Principal:
Humains
/
Angiotensine-II
/
Récepteurs aux angiotensines
/
Inhibiteurs de l'enzyme de conversion de l'angiotensine
/
Cytokines
/
Stress oxydatif
/
Acides gras insaturés
/
Inflammation
/
Animaux
langue:
Anglais
Année:
2005
Type:
Article
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