Bronchial hyperresponsiveness in patients with sarcoidosis.
Article
Dans Anglais
| IMSEAR
| ID: sea-95614
ABSTRACT
OBJECTIVE:
To study bronchial hyperresponsiveness (BHR) in patients with sarcoidosis.METHODS:
Twenty freshly diagnosed patients with sarcoidosis were evaluated. Progressively increasing concentrations of methacholine were administered using a standard five-breath dosimeter protocol, and spirometry performed after each challenge. BHR was expressed as PC20 (provocating concentration of methacholine resulting in 20% fall in forced expiratory volume in first second). All patients were nonsmokers, had no other concurrent cardiopulmonary disease, and were not on any specific treatment for sarcoidosis.RESULTS:
Borderline (PC20 4.0-16.0 mg/mL), mild (PC20 1.0-4.0 mg/mL) and moderate to severe (PC20 <1.0 mg/mL) BHR was documented in three (15%), one (5%) and five (25%) patients respectively. Patients with BHR were similar to those having normal reactivity in terms of age, gender, disease duration and results of pulmonary function testing. All patients with endobronchial disease had BHR.CONCLUSION:
BHR may be seen in several patients of sarcoidosis and could possibly contribute to decline in lung function.
Texte intégral:
Disponible
Indice:
IMSEAR (Asie du Sud-Est)
Sujet Principal:
Spirométrie
/
Indice de gravité de la maladie
/
Tests de provocation bronchique
/
Femelle
/
Humains
/
Mâle
/
Chlorure de méthacholine
/
Hyperréactivité bronchique
/
Sarcoïdose pulmonaire
/
Adulte
Type d'étude:
Guide de pratique
langue:
Anglais
Année:
2004
Type:
Article
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