Research progress in the mechanism and treatment of osteosarcoma / 中华医学杂志(英文版)
Chinese Medical Journal
;
(24): 2412-2420, 2023.
Article
Dans Anglais
| WPRIM
| ID: wpr-1007668
ABSTRACT
Osteosarcoma (OS) is the most common primary malignant bone tumor that more commonly occurs in children and adolescents. The most commonly used treatment for OS is surgery combined with chemotherapy, but the treatment outcomes are typically unsatisfactory. High rates of metastasis and post-treatment recurrence rates are major challenges in the treatment of OS. This underlines the need for studying the in-depth characterization of the pathogenetic mechanisms of OS and development of more effective therapeutic modalities. Previous studies have demonstrated the important role of the bone microenvironment and the regulation of signaling pathways in the occurrence and development of OS. In this review, we discussed the available evidence pertaining to the mechanisms of OS development and identified therapeutic targets for OS. We also summarized the available treatment modalities for OS and identified future priorities for therapeutics research.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Os et tissu osseux
/
Tumeurs osseuses
/
Transduction du signal
/
Ostéosarcome
/
Résultat thérapeutique
/
Microenvironnement tumoral
Limites du sujet:
Adolescent
/
Enfant
/
Humains
langue:
Anglais
Texte intégral:
Chinese Medical Journal
Année:
2023
Type:
Article
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