Role of NLRP3 inflammasome in diabetes mellitus and exercise intervention / 生理学报
Acta Physiologica Sinica
;
(6): 788-798, 2023.
Article
Dans Chinois
| WPRIM
| ID: wpr-1007791
ABSTRACT
Chronic inflammatory reaction has been established as an important sign of the occurrence and development of diabetes mellitus (DM), accompanied by the production of a large number of inflammatory factors, thus aggravating the disease progression. As an important non-invasive intervention measure to inhibit inflammation, exercise plays a very important role in the amelioration of DM. NOD-like receptor protein 3 (NLRP3) inflammasome, a regulatory factor of inflammatory response, can induce a variety of inflammatory cascades and cell death, which are closely related to glucose uptake and dyslipidemia regulation. The development of DM can be postponed with exercise. Previous studies have reported the effects of NLRP3 inflammasome on DM, but the crucial role of exercise in this process remains unclear. Therefore, this paper reviews the research progress on the improving effects of exercise intervention on the symptoms of DM by mediating NLRP3 inflammasome, providing a novel theoretical foundation for understanding the prevention and treatment of DM through exercise.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Diabète
/
Traitement par les exercices physiques
/
Inflammasomes
/
Protéines NLR
/
Protéine-3 de la famille des NLR contenant un domaine pyrine
/
Inflammation
Limites du sujet:
Humains
langue:
Chinois
Texte intégral:
Acta Physiologica Sinica
Année:
2023
Type:
Article
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