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Preparation of Cangai oil transfersomes patches and its in vitro evaluation / 中国中药杂志
China Journal of Chinese Materia Medica ; (24): 854-860, 2020.
Article Dans Chinois | WPRIM | ID: wpr-1008511
ABSTRACT
L_9(3~4) orthogonal experiment design was used to optimize the preparation of the patches,and investigate its affecting factors and skin irritation. Eugenol was taken as the index component to study the release behavior in vitro and percutaneous penetration of Cangai oil transfersomes patches by HPLC.The results showed that the optimal prescription for preparing Cangai oil transfersomes patches were Eudragit E100 0.6 g, succinic acid 0.08 g,triethyl citrate 0.25 g,glycerol 0.2 g.Patches prepared by the preferred preparation had a flat appearance without obvious bubbles.The initial adhesion was 18.33±2.52, the stickiness was(30.01±2.45) min,and the peel strength was(5.62±0.95) kN·m~(-1).The results of affecting factors experiment showed the order of factors affecting its adhesion was humidity>temperature>lighting,and the skin irritation test results showed no significant skin irritation after 24 h of single administration. The results of drug release behavior in vitro showed that the release and the percutaneous penetration of both Cangai oil patches and Cangai oil transfersomes patches conformed to the Higuchi equation.The release amount of eugenol were 80.66% and 82.25% at 72 h, with no significant difference. The cumulative permeation area of eugenol per unit area reached(0.195 6±0.065 9),(0.131 0±0.045 5) mg·cm~(-2) at 72 h, with significant differences(P<0.05).The experiment results proved that the preparation process of Cangai oil transfersomes patches was stable,and the prepared patches had a good adhesion. At the same time,the preparation of transfersomes patches could alleviate and control the release of the drug to a certain extent, and provide a certain experimental basis for clinical pediatric drug safety.
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Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Poly(acides méthacryliques) / Peau / Absorption cutanée / Administration par voie cutanée / Huiles végétales / Vecteurs de médicaments / Patch transdermique / Libération de médicament Limites du sujet: Humains langue: Chinois Texte intégral: China Journal of Chinese Materia Medica Année: 2020 Type: Article

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Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Poly(acides méthacryliques) / Peau / Absorption cutanée / Administration par voie cutanée / Huiles végétales / Vecteurs de médicaments / Patch transdermique / Libération de médicament Limites du sujet: Humains langue: Chinois Texte intégral: China Journal of Chinese Materia Medica Année: 2020 Type: Article