Identification of chemical constituents in Guizhi Fuling Capsules by UPLC-Q-TOF-MS/MS / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 861-877, 2020.
Article
Dans Chinois
| WPRIM
| ID: wpr-1008512
ABSTRACT
To qualitatively characterize the chemical composition of Guizhi Fuling Capsules using UPLC-ESI-Q-TOF-MS/MS. The analysis was performed on Agilent ZORBAX RRHD Eclipes Plus C_(18)(2.1 mm×100 mm, 1.8 μm) column,that was eluted with mobile phase consisting of acetonitrile and 0.1% formic acid in a gradient mode. The flow rate was 0.4 mL·min~(-1), and column temperature was 30 ℃. Tandem mass spectrometry was acquired in both negative and positive ESI modes. These components were further analyzed based on high-resolution mass-to-charge ratios, fragment ion species, reference substances and literature data. In conclusion, a total of 200 compounds were identified, in which 40 were verified with reference substances. The current study laid a foundation for in-depth studies of its mass balance and pharmacodynamics.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Capsules
/
Médicaments issus de plantes chinoises
/
Chromatographie en phase liquide à haute performance
/
Spectrométrie de masse en tandem
langue:
Chinois
Texte intégral:
China Journal of Chinese Materia Medica
Année:
2020
Type:
Article
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