Research progress on immunotherapy based on NK cells for hepatocellular carcinoma / 细胞与分子免疫学杂志
Chinese Journal of Cellular and Molecular Immunology
;
(12): 80-88, 2024.
Article
Dans Chinois
| WPRIM
| ID: wpr-1009479
ABSTRACT
Hepatocellular carcinoma (HCC) is well characterized as a heterogeneous disease. Its late-stage diagnosis and chemotherapy resistance make it one of the refractory tumors in China. Natural killer (NK) cells play a significant role in immune surveillance. However, NK cells become dysfunctional in the progression of HCC, leading to tumor immune escape. This article reviews the recent progress on different strategies of NK cell-based immunotherapy in treating HCC, including direct adoptive NK cell transfer, gene engineering in NK cell, NK cell receptor targeting, immunosuppressive microenvironment modification, and tumor toxicity enhancement by cytokines or traditional Chinese medicine. These NK cell-based strategies have shown promising therapeutic potential.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Cellules tueuses naturelles
/
Carcinome hépatocellulaire
/
Récepteurs de cellules tueuses naturelles
/
Microenvironnement tumoral
/
Immunothérapie
/
Tumeurs du foie
Limites du sujet:
Humains
langue:
Chinois
Texte intégral:
Chinese Journal of Cellular and Molecular Immunology
Année:
2024
Type:
Article
Documents relatifs à ce sujet
MEDLINE
...
LILACS
LIS