Research progress on immunological properties of ESAT-6 secreted by Mycobacterium tuberculosis and its role in new vaccines / 细胞与分子免疫学杂志
Chinese Journal of Cellular and Molecular Immunology
; (12): 89-94, 2024.
Article
de Zh
| WPRIM
| ID: wpr-1009480
Bibliothèque responsable:
WPRO
ABSTRACT
Early secreted antigenic target of 6 kDa protein (ESAT-6) is the major virulence factor of Mycobacterium tuberculosis (MTB), which can resist the clearance of MTB in bodies by inhibiting macrophage phagocytosis and autophagy reaction, thus impeding the immune defense function of the body against MTB infection. In addition, ESAT-6-induced apoptosis of macrophage and massive necrosis of innate immune cells can foster MTB proliferation and colonization, leading to systemic MTB infection. Moreover, ESAT-6 hampers the protective immune response of Th1 cells, reducing the secretion of pro-inflammatory cytokines and contributing to immune dysfunction, thus accelerating the course of MTB infection. During the process, the high immunogenicity of ESAT-6 can be leveraged as a dominant antigen in the development of new TB vaccines, making it a promising candidate with broad prospects for further development.
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Autophagie
/
Vaccins
/
Cytokines
/
Apoptose
/
Sepsie
/
Mycobacterium tuberculosis
Limites du sujet:
Humans
langue:
Zh
Texte intégral:
Chinese Journal of Cellular and Molecular Immunology
Année:
2024
Type:
Article