Heavy cigarette smoking and alcohol consumption are associated with impaired sperm parameters in primary infertile men / 亚洲男科学杂志(英文版)
Asian Journal of Andrology
;
(6): 478-485, 2019.
Article
Dans Anglais
| WPRIM
| ID: wpr-1009701
ABSTRACT
We assessed the concomitant impact of cigarette smoking and alcohol consumption in men presenting for primary couple's infertility. Data from 189 infertile men were analyzed. Semen analysis, serum hormones, and sperm DNA fragmentation (SDF) were obtained. Smoking status was categorized as follows current nonsmoker (-S), moderate smoker (+MS), and heavy smoker (+HS). Alcohol consumption was categorized as follows abstainer (-D), moderate drinker (+MD), and heavy drinker (+HD). Descriptive statistics and logistic regression models were applied. Among all the participants, 132 (69.8%), 30 (15.9%), and 27 (14.3%) patients were -S, +MS, and +HS, respectively. In addition, 67 (35.4%), 77 (40.7%) and 45 (23.8%) men were -D, +MD and +HD, respectively. Regarding concomitant habits, 52 (27.5%) patients were nonsmokers and abstainers (-S/-D Group 1), 91 (48.1%) had at least one recreational habit (-S/+D or +S/-D Group 2), and 46 (24.3%) were both smokers and drinkers (+S/+D Group 3). Sperm concentration and progressive motility were lower in +HS and +HD, compared with -S and -D (all P < 0.05), respectively. Similarly, both parameters were significantly lower in Group 3 than Groups 1 and 2 (all P < 0.05). SDF values were higher in Group 3 than Groups 1 and 2 (both P < 0.05). In multivariate analysis, follicle-stimulating hormone (FSH) levels and concomitant +S/+D status were independent predictors of impaired sperm concentration and progressive motility (all P < 0.05). Heavy smoking and heavy drinking were associated with worse seminal parameters than moderate smoking/drinking and nonsmoking/abstaining. When concomitant, +S/+D status has an even greater detrimental effect on semen parameters.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Numération des spermatozoïdes
/
Mobilité des spermatozoïdes
/
Spermatozoïdes
/
Consommation d'alcool
/
Études de cohortes
/
Alcoolisme
/
Analyse du sperme
/
Fumer des cigarettes
/
Hormone folliculostimulante
/
Infertilité masculine
Limites du sujet:
Adulte
/
Femelle
/
Humains
/
Mâle
langue:
Anglais
Texte intégral:
Asian Journal of Andrology
Année:
2019
Type:
Article
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