Research progress on the roles of neurovascular unit in stroke-induced immunosuppression / 浙江大学学报·医学版
Journal of Zhejiang University. Medical sciences
;
(6): 662-672, 2023.
Article
Dans Chinois
| WPRIM
| ID: wpr-1009926
ABSTRACT
A complex pathophysiological mechanism is involved in brain injury following cerebral infarction. The neurovascular unit (NVU) is a complex multi-cellular structure consisting of neurons, endothelial cells, pericyte, astrocyte, microglia and extracellular matrix, etc. The dyshomeostasis of NVU directly participates in the regulation of inflammatory immune process. The components of NVU promote inflammatory overreaction and synergize with the overactivation of autonomic nervous system to initiate stroke-induced immunodepression (SIID). SIID can alleviate the damage caused by inflammation, however, it also makes stroke patients more susceptible to infection, leading to systemic damage. This article reviews the mechanism of SIID and the roles of NVU in SIID, to provide a perspective for reperfusion, prognosis and immunomodulatory therapy of cerebral infarction.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Infarctus cérébral
/
Immunosuppression thérapeutique
/
Accident vasculaire cérébral
/
Cellules endothéliales
/
Neurones
Limites du sujet:
Humains
langue:
Chinois
Texte intégral:
Journal of Zhejiang University. Medical sciences
Année:
2023
Type:
Article
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