Hypothesis of Genetic Diversity Selection in the Occurrence and Development of
Lung Cancer: Molecular Evolution and Clinical Significance / 中国肺癌杂志
Chinese Journal of Lung Cancer
;
(12): 943-949, 2024.
Article
Dans Chinois
| WPRIM
| ID: wpr-1010102
ABSTRACT
So far, the monoclonal hypothesis of tumor occurrence and development cannot be justified. The genetic diversity selection hypothesis for the occurrence and development of lung cancer links Mendelian genetics with Darwin's theory of evolution, suggesting that the genetic diversity of tumor cell populations with polyclonal origins-monoclonal selection-subclonal expansion is the result of selection pressure. Normal cells acquire mutations in oncogenic driver genes and have a selective advantage over other cells, becoming tumor initiating cells; In the interaction with the tumor microenvironment (TME), the vast majority of initiating cells are recognized and killed by the human immune system. If immune escape occurs, the incidence of malignant tumors will greatly increase, and subclonal expansion, intratumour heterogeneity, etc. will occur. This article proposed the hypothesis of genetic diversity selection and analyzed its clinical significance.
.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Évolution moléculaire
/
Microenvironnement tumoral
/
Pertinence clinique
/
Tumeurs du poumon
/
Mutation
Limites du sujet:
Humains
langue:
Chinois
Texte intégral:
Chinese Journal of Lung Cancer
Année:
2024
Type:
Article
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