Research Advance of Chinese Medicine in Treating Atherosclerosis: Focus on Lipoprotein-Associated Phospholipase A2 / 中国结合医学杂志
Chinese journal of integrative medicine
;
(12): 277-288, 2024.
Article
Dans Anglais
| WPRIM
| ID: wpr-1010331
ABSTRACT
As a serious cardiovascular disease, atherosclerosis (AS) causes chronic inflammation and oxidative stress in the body and poses a threat to human health. Lipoprotein-associated phospholipase A2 (Lp-PLA2) is a member of the phospholipase A2 (PLA2) family, and its elevated levels have been shown to contribute to AS. Lp-PLA2 is closely related to a variety of lipoproteins, and its role in promoting inflammatory responses and oxidative stress in AS is mainly achieved by hydrolyzing oxidized phosphatidylcholine (oxPC) to produce lysophosphatidylcholine (lysoPC). Moreover, macrophage apoptosis within plaque is promoted by localized Lp-PLA2 which also promotes plaque instability. This paper reviews those researches of Chinese medicine in treating AS via reducing Lp-PLA2 levels to guide future experimental studies and clinical applications related to AS.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Marqueurs biologiques
/
1-Alkyl-2-acetylglycerophosphocholine esterase
/
Athérosclérose
/
Plaque d'athérosclérose
/
Lipoprotéines
/
Médecine traditionnelle chinoise
Limites du sujet:
Humains
langue:
Anglais
Texte intégral:
Chinese journal of integrative medicine
Année:
2024
Type:
Article
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