CX3CR1 contributes to streptozotocin-induced mechanical allodynia in the mouse spinal cord / 浙江大学学报(英文版)(B辑:生物医学和生物技术)
Journal of Zhejiang University. Science. B
;
(12): 166-171, 2020.
Article
Dans Anglais
| WPRIM
| ID: wpr-1010523
ABSTRACT
Patients with diabetic peripheral neuropathy experience debilitating pain that significantly affects their quality of life (Abbott et al., 2011), by causing sleeping disorders, anxiety, and depression (Dermanovic Dobrota et al., 2014). The primary clinical manifestation of painful diabetic neuropathy (PDN) is mechanical hypersensitivity, also known as mechanical allodynia (MA) (Callaghan et al., 2012). MA's underlying mechanism remains poorly understood, and so far, based on symptomatic treatment, it has no effective therapy (Moore et al., 2014).
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Moelle spinale
/
Streptozocine
/
Diabète expérimental
/
Diabète de type 1
/
Neuropathies diabétiques
/
Chimiokine CX3CL1
/
Récepteur-1 de la chimiokine CX3C
/
Hyperalgésie
/
Souris de lignée C57BL
Limites du sujet:
Animaux
langue:
Anglais
Texte intégral:
Journal of Zhejiang University. Science. B
Année:
2020
Type:
Article
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