Roles of pattern recognition receptors in diabetic nephropathy / 浙江大学学报(英文版)(B辑:生物医学和生物技术)
Journal of Zhejiang University. Science. B
;
(12): 192-203, 2020.
Article
Dans Anglais
| WPRIM
| ID: wpr-1010527
ABSTRACT
Diabetic nephropathy (DN) is currently the most common complication of diabetes. It is considered to be one of the leading causes of end-stage renal disease (ESRD) and affects many diabetic patients. The pathogenesis of DN is extremely complex and has not yet been clarified; however, in recent years, increasing evidence has shown the important role of innate immunity in DN pathogenesis. Pattern recognition receptors (PRRs) are important components of the innate immune system and have a significant impact on the occurrence and development of DN. In this review, we classify PRRs into secretory, endocytic, and signal transduction PRRs according to the relationship between the PRRs and subcellular compartments. PRRs can recognize related pathogen-associated molecular patterns (PAMPs) and danger-associated molecular patterns (DAMPs), thus triggering a series of inflammatory responses, promoting renal fibrosis, and finally causing renal impairment. In this review, we describe the proposed role of each type of PRRs in the development and progression of DN.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Protéine C-réactive
/
Composant sérique amyloïde P
/
Transduction du signal
/
Lectine liant le mannose
/
Néphropathies diabétiques
/
Endocytose
/
Récepteurs de reconnaissance de motifs moléculaires
/
Alarmines
/
Molécules contenant des motifs associés aux pathogènes
/
Immunité innée
Limites du sujet:
Humains
langue:
Anglais
Texte intégral:
Journal of Zhejiang University. Science. B
Année:
2020
Type:
Article
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