Crosstalk Between Peripheral Innervation and Pancreatic Ductal Adenocarcinoma / 神经科学通报·英文版
Neuroscience Bulletin
; (6): 1717-1731, 2023.
Article
de En
| WPRIM
| ID: wpr-1010643
Bibliothèque responsable:
WPRO
ABSTRACT
Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive lethal malignancy, characterized by late diagnosis, aggressive growth, and therapy resistance, leading to a poor overall prognosis. Emerging evidence shows that the peripheral nerve is an important non-tumor component in the tumor microenvironment that regulates tumor growth and immune escape. The crosstalk between the neuronal system and PDAC has become a hot research topic that may provide novel mechanisms underlying tumor progression and further uncover promising therapeutic targets. In this review, we highlight the mechanisms of perineural invasion and the role of various types of tumor innervation in the progression of PDAC, summarize the potential signaling pathways modulating the neuronal-cancer interaction, and discuss the current and future therapeutic possibilities for this condition.
Mots clés
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Tumeurs du pancréas
/
Nerfs périphériques
/
Transduction du signal
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Carcinome du canal pancréatique
/
Microenvironnement tumoral
Limites du sujet:
Humans
langue:
En
Texte intégral:
Neuroscience Bulletin
Année:
2023
Type:
Article