Six new coumarins from the roots of Toddalia asiatica and their anti-inflammatory activities / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.)
;
(6): 852-858, 2023.
Article
Dans Anglais
| WPRIM
| ID: wpr-1010996
ABSTRACT
We reported the discovery of six novel coumarins, toddasirins A-F (1-6), each endowed with modified isoprenyl or geranyl side chains, derived from the roots of Toddalia asiatica. Comprehensive structural elucidation was achieved through multispectroscopic analyses, single-crystal X-ray diffraction experiments, and advanced quantum mechanical electronic circular dichroism (ECD) calculations. Furthermore, the anti-inflammatory activity of these compounds was assessed. Notably, compounds 1-3 and 6 demonstrated notable inhibitory effects on nitric oxide (NO) production in lipopolysaccharide (LPS)-induced RAW 264.7 cells, with 50% inhibitory concentration (IC50) values of 3.22, 4.78, 8.90, and 4.31 μmol·L-1, respectively.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Extraits de plantes
/
Structure moléculaire
/
Coumarines
/
Rutaceae
/
Anti-inflammatoires
/
Monoxyde d'azote
Limites du sujet:
Animaux
langue:
Anglais
Texte intégral:
Chinese Journal of Natural Medicines (English Ed.)
Année:
2023
Type:
Article
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