Outcomes of reduced-intensity conditioning allogeneic hematopoietic stem cell transplantation for 10 patients with myelofibrosis / 中华血液学杂志
Chinese Journal of Hematology
;
(12): 225-230, 2018.
Article
Dans Chinois
| WPRIM
| ID: wpr-1011729
ABSTRACT
Objective:
To evaluate the efficacy of reduced-intensity conditioning allogeneic hematopoietic stem cell transplantation (RIC-allo-HSCT) for patients with myelofibrosis (MF).Methods:
The clinical data of 10 patients with myelofibrosis (MF) who underwent RIC-allo-HSCT.Results:
Of all 10 patients, 6 were male and 4 women, with a median age of 28.5 (22-54). Using fludarabine/busulfan plus total body irradiation (FB+TBI) pretreatment scheme based. Hematopoiesis reconstitution was achieved in 9 patients (90%). The median time of neutrophil and platelet engraftment was 13.5 (10-22) day and 16.5 (13-40) day, respectively. Acute GVHD occurred in 4 cases while chronic GVHD in 5 cases. The prospective OS for 3 years was (90.0±8.5)% after a median follow-up time of 17 months. Transplant related mortality was 1 case.Conclusion:
RIC-HSCT with FB+TBI is a feasible and effective alternative for MF patients.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Vidarabine
/
Busulfan
/
Études prospectives
/
Transplantation de cellules souches hématopoïétiques
/
Conditionnement pour greffe
/
Myélofibrose primitive
/
Maladie du greffon contre l'hôte
Limites du sujet:
Adulte
/
Femelle
/
Humains
/
Mâle
langue:
Chinois
Texte intégral:
Chinese Journal of Hematology
Année:
2018
Type:
Article
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