The clinical observation of serum specific biomarkers in patients with chronic graft-versus-host disease / 中华血液学杂志
Chinese Journal of Hematology
;
(12): 948-952, 2019.
Article
Dans Chinois
| WPRIM
| ID: wpr-1012102
ABSTRACT
Objective:
Chronic graft-versus-host disease (cGVHD) is a major long-term complication after allogeneic hematopoietic stem cell transplantation (allo-HSCT) . It is important to study the changes of serum biomarkers expression in patients for early diagnosis and treatment.Methods:
The expression levels of five serum protein markers (IL-1b, IL-16, CXCL9, CCL19, CCL17) in patients with or without cGVHD after allo-HSCT were detected by liquid suspension microarray.Results:
Compared with the control group without cGVHD, the expression levels of CXCL9 and CCL17 in serum of patients with cGVHD were significantly increased (P<0.05) . CCL17 was correlated with the severity of cGVHD (P<0.001) . CXCL9 was significantly increased in the serum of patients with skin lesion (P<0.01) , and CCL17 was significantly expressed in cGVHD patients with liver as the target organ (P<0.01) .Conclusion:
The combination of CXCL9 and CCL17 can be used as serum biomarkers of cGVHD, which has certain reference value in assisting the diagnosis and evaluation of cGVHD severity.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Transplantation homologue
/
Marqueurs biologiques
/
Maladie chronique
/
Transplantation de cellules souches hématopoïétiques
/
Maladie du greffon contre l'hôte
Limites du sujet:
Humains
langue:
Chinois
Texte intégral:
Chinese Journal of Hematology
Année:
2019
Type:
Article
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