Advances of studies on role of microRNAs in regulating blood-brain barrier integrity in ischemic stroke / 中国药理学通报

ABSTRACT

The destruction of the blood-brain barrier, one of the main pathological processes of ischemic stroke, has become a new target for the treatment of ischemic stroke. miRNAs are versatile regulatory molecules that influence almost every aspect of BBB structure and function. This review summarizes the recent progress in studies on the role of miRNAs in BBB dysfunction in hypoxic/ischemic brain injury, and highlights the specific and key role of miRNAs in the regulation of BBB structure and function in ischemic stroke.