Role and research progress of endoplasmic reticulum stress in anti -tumor therapy / 中国药理学通报

ABSTRACT

In the process of tumor occurrence, development and metastasis, the stress environment experienced by tumor cells such as hypoxia, low glucose, acidosis, can cause tumor cells to undergo endoplasmic reticulum stress (E R S). In order to restore cell homeostasis, ERS initiates the unfolded protein response (U P R). But when ERS exceeds the survival ability of cells, it will mediate cell apoptosis. This article expounds the role of ERS in anti-tumor therapy and its research progress mainly from the two aspects of inhibition of UPR mediated promote survival pathways and induction of ERS mediated death pathways, in order to understand the relationship between ERS-related pathways and anti-tumor treatments, hoping to provide new ideas for tumor treatment.