Research Progress on Factors Associated With Failure of Helicobacter pylori Eradication / 胃肠病学

ABSTRACT

Helicobacter pylori (Hp) is the main pathogenic factor of gastrointestinal diseases, and has a certain relationship with a variety of extra⁃gastrointestinal diseases. In recent years, the resistance rate of Hp to antibiotics has been increasing, resulting in a significant decline in the effectiveness of traditional proton pump inhibitor⁃based triple therapy in the first⁃line treatment. Therefore, the latest consensus report in China has adopted bismuth quadruple therapy as the main empirical treatment for the eradication of Hp. However, the success rate of Hp eradication still has not reached higher than 85% in recent years. This article reviewed the research progress on factors associated with failure of Hp eradication, in order to provide a reference for early intervention, optimization of diagnosis and therapy, and improvement of Hp eradication rate.