Advances in Study on Role of Neutrophil Infiltration in Helicobacter pylori Infection-related Diseases / 胃肠病学
Chinese Journal of Gastroenterology
; (12): 696-699, 2020.
Article
de Zh
| WPRIM
| ID: wpr-1016301
Bibliothèque responsable:
WPRO
ABSTRACT
Helicobacter pylori (Hp) is a microaerophilic Gram-negative bacterium that colonizes the gastric mucosa. After colonization, many proteins expressed by Hp, such as Helicobacter pylori urease (HPU), neutrophil-activating protein (NAP), outer membrane protein (OMP), cytotoxin-associated gene A (CagA) and vacuolating cytotoxin A (VacA), may serve as antigens to mediate neutrophil chemotaxis. Thereafter, neutrophils infiltrate in gastric mucosa and play roles in mucosal immunity via secreting cytokines and releasing reactive oxygen species (ROS) and myeloperoxidase (MPO). This article reviewed the advances in study on the role of neutrophil infiltration in Hp infection-related diseases.
Texte intégral:
1
Indice:
WPRIM
langue:
Zh
Texte intégral:
Chinese Journal of Gastroenterology
Année:
2020
Type:
Article