Current status and influencing factors of sleep behavior disorders in elderly patients with Alzheimer's disease / 公共卫生与预防医学

ABSTRACT

Objective To analyze the current status and influencing factors of sleep behavior disorders in elderly patients with Alzheimer's disease (AD). Methods The clinical data of 420 elderly patients with AD were collected retrospectively. The REM sleep behavior disorder questionnaire-Hong Kong (RBDQ-HK) was used to evaluate the status of sleep behavior disorders. Based on the evaluation results, the patients were divided into sleep behavior disorder group and non-sleep behavior disorder group. Logistic regression analysis was conducted to identify the influencing factors of sleep behavior disorders in elderly patients with AD. The correlation between sleep behavior disorders and the Pittsburgh Sleep Quality Index (PQSI) score, Mini Mental State Examination (MMSE) score, Hamilton Anxiety Scale (HAMA) score and Hamilton Depression Scale (HAMD) score was analyzed. Results Among the 420 patients, there were 227 (54.05%) patients with sleep behavior disorders. Gender, course of disease, disease severity, PQSI score, HAMA score and HAMD score were risk factors for sleep behavior disorders, while education level, standardized medication and MMSE score were protective factors (P<0.05). PQSI score, HAMA score and HAMD score were positively correlated with the RBDQ-HK score. The MMSE score was negatively correlated with the RBDQ-HK score (P<0.05). Conclusion Sleep behavior disorders are common in elderly patients with AD. Female patients, patients with low education level, patients with long course of disease and patients in severe condition are at high risk of developing sleep behavior disorders. Clinically, alleviating anxiety and depression and improving sleep quality and cognitive function may help to prevent the occurrence of sleep behavior disorders.