Changes of antithroglobulin antibody in children with congenital hypothyroidism
Annals of Pediatric Endocrinology & Metabolism
;
: 179-182, 2013.
Article
Dans Anglais
| WPRIM
| ID: wpr-10174
ABSTRACT
PURPOSE:
It has been reported that antithroglobulin (anti-TG) antibody is increased in the sera of both children with transient congenital hypothyroidism and their mothers. And transplacental transport of thyroid autoantibody was proposed as the pathogenesis of transient congenital hypothyroidism. However this is not known in nontransient congenital hypothyroidism. This study was done to see changes of anti-TG antibody in children with nontransient congenital hypothyroidism.METHODS:
Study patients consisted of 60 patients diagnosed as congenital hypothyroidism in the Department of Pediatrics, Kyungpook National University Children's Hospital, Daegu, Republic of Korea between January 2010 and March 2013. Healthy control were 45 children showing normal thyroid function. Anti-TG antibody and various laboratory tests were analyzed retrospectively, and compared in both children with congenital hypothyroidism and controls.RESULTS:
Anti-TG antibody was significantly higher in children with congenital hypothyroidism compared to healthy controls, 119.4+/-34.7 U/mL versus 80.6+/-19.6 U/mL, respectively (P<0.001). There was no significant difference of anti-TG antibody in gender and age.CONCLUSION:
We observed a significant increase of anti-TG antibody in children with nontransient congenital hypothyroidism compared to healthy controls. Further study focusing pathogenetic role of anti-TG antibody in nontransient congenital hypothyroidism is necessary. Furthermore, the clinical significance in the course of congenital hypothyroidism need to be known.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Pédiatrie
/
Autoanticorps
/
Glande thyroide
/
Études rétrospectives
/
Hypothyroïdie congénitale
/
République de Corée
/
Mères
Type d'étude:
Étude observationnelle
Limites du sujet:
Enfant
/
Humains
Pays comme sujet:
Asie
langue:
Anglais
Texte intégral:
Annals of Pediatric Endocrinology & Metabolism
Année:
2013
Type:
Article
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