Research progress of no-reflow phenomenon after revascularization in acute ischemic stroke / 临床神经病学杂志

ABSTRACT

Intravenous thrombolysis and revascularization in the time window are effective in promoting blood flow recanalization,reducing core infarction area and improving clinical prognosis in acute ischemic stroke(AIS).However,successful vascular recanalization does not mean the complete recovery of cerebral microcirculation perfusion,and the microstructure damage during ischemia may lead to microcirculation"no-reflow phenomenon(NRP)".In recent years,studies have found that about 40%of patients with AIS can have NRP after vascular recanalization,which is one of the important reasons for futile recanalization after vascular therapy in AIS.Therefore,early identification and treatment of NRP after recanalization treatment of AIS is of great significance to improve the prognosis.This article reviews the related definition,pathophysiological mechanism,imaging features and treatment strategies of NRP after vascular recanalization in AIS,in order to provide a reference for clinical diagnosis and treatment after vascular recanalization in AIS.