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Clinical manifestations of nodo-paranodopathy with anti-neurofascin 186 antibody positive(report of one case) / 临床神经病学杂志
Article de Zh | WPRIM | ID: wpr-1019226
Bibliothèque responsable: WPRO
ABSTRACT
Objective To investigate the clinical manifestations of nodo-paranodopathy(NPP)with anti-neurofascin 186(NF186)antibody positive.Methods The clinical data of a NPP patient with cranial nerve damage caused by anti-NF186 antibody positive was retrospectively analyzed.Results The patient was a 70-year-old male with sudden speech disorder and dysphagia one month ago.Glucocorticoid therapy was discontinued after improvement.The patient's speech,swallowing,chewing,bristling,turning and head-up movements were laborious and progressively aggravated 5 days ago.The EMG examination of the limbs was normal,and the serum and CSF anti-NF186 antibody were positive.The curative effect of glucocorticoid treatment was not obvious,and the symptoms were significantly improved after plasma exchange treatment.Conclusions Anti-NF186 antibody-positive NPP has late onset age,severe illness and accompanied with cranial nerves damage.Conventional hormone therapy is not effective,but plasma exchange therapy is effective.
Mots clés
Texte intégral: 1 Indice: WPRIM langue: Zh Texte intégral: Journal of Clinical Neurology Année: 2024 Type: Article
Texte intégral: 1 Indice: WPRIM langue: Zh Texte intégral: Journal of Clinical Neurology Année: 2024 Type: Article