Influence of PCI combined ticagrelor on cardiac function and vascular endothelial function in patients with acute myocardial infarction / 心血管康复医学杂志

ABSTRACT

Objective:To explore the influence of percutaneous coronary intervention(PCI)combined ticagrelor on cardiac function and vascular endothelial function in patients with acute myocardial infarction(AMI).Methods:A total of 100 AMI patients treated in our hospital were selected.According to the crossover double-blind method,they were divided into PCI group(n=50,received PCI treatment)and combined treatment group(n=50,received ticagrelor antiplatelet therapy based on PCI treatment).Inflammatory factor levels,endothelial function indexes before and 7d after treatment,cardiac function indexes before and four weeks after treatment were compared be-tween two groups.Results:Compared with before treatment,there were significant improvements in inflammatory factors,endothelial function and cardiac function in two groups after treatmen.t Compared with PCI group after treatment,there were significant reductions in levels of interleukin(IL)-6[(4.25±0.34)pg/ml vs.(3.25±0.25)pg/ml],C reactive protein(CRP)[(9.25±1.08)mg/L vs.(6.96±0.67)mg/L],procalcitonin(PCT)[(2.11±0.14)g/L vs.(1.65±0.11)g/L],ventricular endothelial growth factor(VEGF)[(304.95±28.36)pg/L vs.(232.36±22.30)pg/L],endothelin(ET)-1[(59.33±6.31)ng/L vs.(41.83±4.65)ng/L],left ven-tricular end-diastolic diameter(LVEDd)[(48.75±3.69)mm vs.(36.53±3.02)mm]and left ventricular end-systolic diameter(LVESd)[(44.25±3.75)mm vs.(37.59±3.97)mm],and significant rise in LVEF[(46.12±4.97)%vs.(50.87±5.31)%]in combined treatment group,P=0.001 all.Conclusion:PCI combined ticagrelor can effectively relieve inflammatory stress state,help the recovery of heart function and improvement of vascular endothelial function in AMI patients,which is worthy ofpromotion.