Research progress on the role of non-coding RNA in the occurence,development and treatment of osteonecrosis of the femoral head / 新乡医学院学报

ABSTRACT

Osteonecrosis of the femoral head(ONFH)is a common and intractable disease in orthopedics,and its occurrence is associated with lipid metabolism disorders,endothelial dysfunction,bone homeostasis imbalance,genetic polymorphism,etc.However,the specific mechanism has not been fully elucidated.ONFH has an insidious progression in the early stages,and in the later stages,it often requires hip replacement surgery,which imposes a heavy economic burden on patients and society.Non-coding RNA has been the hotspot of medical research in recent years,and increasing number of non-coding RNA has been found to regulate the occurrence and development of ONFH through various mechanisms.This article reviews the research progress on the role of non-coding RNA in the occurence,development and treatment of ONFH,in order to provide reference for the treatment of ONFH.