Value of color Doppler ultrasound examination in the diagnosis of breast cancer with microcalcifications and the influential factors / 中国基层医药

ABSTRACT

Objective:To analyze the value of color Doppler ultrasound examination in the diagnosis of breast cancer with microcalcifications.Methods:A total of 145 patients with breast cancer who received treatment in Weihai Central Hospital from August 2016 to August 2020 were included in this study. All of these patients underwent X-ray photography, ultrasound examination, and pathological examination. They were divided into ultrasound results-positive group and ultrasound results-negative group. Univariate and multivariate logistic analyses were performed to analyze the factors related to sensitivity of ultrasound examination for identifying breast cancer with microcalcifications.Results:Among 145 patients with breast cancer with microcalcifications, 80 patients (55.17%) had ductal carcinoma in situ and 65 cases (44.83%) had invasive carcinoma. Histological grade I, II, III carcinoma and carcinoma of unknown grading were found in 14 patients (9.66%), 91 patients (62.76%), 37 patients (25.52%), and 3 patients (2.07%), respectively. The sensitivity of color Doppler ultrasound in identifying breast cancer with microcalcifications was 81.38%. The results of logistic regression analysis showed that pathological type invasive carcinoma, the size of microcalcification > 2 cm, and the shape of microcalcification being polymorphic were the factors that affect the sensitivity of color Doppler ultrasound for identifying breast cancer with microcalcifications. The tumor size measured by pathology, X-ray photography, and ultrasound was (2.02 ± 0.45) cm, (2.45 ± 0.36) cm, and (2.14 ± 0.38) cm, respectively. There was a significant correlation in tumor size between X-ray photography and ultrasound measurement results and pathological measurement results ( r = 0.58, 0.73, both P < 0.05). The tumor size measured by ultrasound, compared with that measured by X-ray photography, was closer to pathological measurement result. Conclusion:Color Doppler ultrasound has a high sensitivity in identifying breast cancer with microcalcifications, but it is greatly affected by pathological type, microcalcification morphology and microcalcification size. The tumor sizes measured by color Doppler ultrasound and X-ray photography are slightly larger than pathological measurement results, but the tumor sizes measured by color Doppler ultrasound are closer to the pathological measurement results.