Neuroimaging research status of persistent postural-perceptual dizziness / 中风与神经疾病杂志

ABSTRACT

@#Persistent postural-perceptual dizziness （PPPD） is a common clinical chronic dizziness disease，with persistent dizziness，instability，or non-rotational vertigo as the main symptom. It may be aggravated by postural changes，active/passive movements，and exposure to complex visual environments. At present，it is believed that the occurrence of PPPD may be related to the failure of postural control readaptation and abnormal cortical multisensory integration，but the specific pathophysiological mechanism is not clear. In recent years，with the continuous application of neuroimaging technology in the field of vertigo diseases，it has been found that in patients with PPPD，the brain structure，function，and connectivity related to vestibular multisensory and spatial orientation are decreased，while the function and connectivity related to visual processing are enhanced. At the same time，various psychiatric factors （such as anxiety，depression，and neuroticism） as well as triggers may be involved in regulating the brain structure of people with PPPD，which helps explain the differences in outcomes between studies. The above neuroimaging findings are helpful for the early diagnosis and treatment of PPPD. Therefore，this paper reviews the neuroimaging studies of PPPD to provide a reference for explaining the pathophysiological mechanism of PPPD.