Research progress on exosomes and their engineering in ischemic stroke / 中风与神经疾病杂志

ABSTRACT

@#Ischemic stroke is a cerebrovascular disease with high disability rate and mortality. At present,there is no effective treatment to promote the recovery of neurological function after ischemic stroke. Exosomes can not only mediate the communication between cells,but also have the ability to cross the blood-brain barrier,so they have received extensive attention in the treatment of ischemic stroke. Exosomes are modified by bioengineering technologies to prepare engineered exosomes with brain targeting and therapeutic effects,which have been applied in the research and treatment of ischemic stroke,in order to improve the repair of neurological function after stroke,reduce the clinical disability rate and mortality,and improve the survival and quality of life of patients. This article reviews exosomes,the role of exosomes in ischemic stroke,and the preparation of engineered exosomes,and discusses the application prospect of engineered exosomes in the treatment of ischemic stroke,with a view to providing a reference for subsequent research.