Analysis of a model based on serum RANTES and MIF for prediction of cognitive dysfunction in patients with Parkinson disease / 中风与神经疾病杂志

ABSTRACT

@#Objective To study the value of regulated upon activation,normal T-cell expressed and secreted (RANTES) and macrophage migration inhibitory factor (MIF) in the prediction of cognitive dysfunction associated with Parkinson disease (PD). Methods A total of 62 PD patients who received treatment in our hospital from January 2020 to January 2022 were recruited. All patients were treated with levodopa for 5 months. The levels of RANTES,MIF,interleukin-6 (IL-6),and tumor necrosis factor (TNF)-α were measured by enzyme-linked immunosorbent assay. Results Among the 62 PD patients,21 (33.87%) developed cognitive dysfunction after 5 months of levodopa treatment. The levels of RANTES,MIF,IL-6,and TNF-α were significantly lower in patients with cognitive dysfunction than in those without cognitive dysfunction (P<0.05). A multiple regression model was established with the basic data of patients as covariates and the presence or absence of cognitive dysfunction as the dependent variable. Adjustment was made for family history of PD,clinical subtype,comorbidity of hypertension,smoking history,course of disease,sex,and age. The results showed that serum RANTES,MIF,IL-6,and TNF-α levels were independent risk factors for cognitive dysfunction in PD patients (P<0.05). The receiver operating characteristic(ROC) curve showed an area under the ROC curve(AUC) of 0.798 for serum RANTES level to predict cognitive dysfunction in PD patients,with specificity,sensitivity,and Youden index of 0.743,0.705,and 0.448,respectively. The AUC was 0.802 for serum MIF level in the prediction of cognitive dysfunction in PD patients,with specificity,sensitivity,and Youden index of 0.552,0.973,and 0.525,respectively. The combination of serum RANTES and MIF had an AUC of 0.958 in predicting cognitive dysfunction in PD patients. Conclusion High levels of serum RANTES and MIF are risk factors for cognitive dysfunction in PD patients. In clinical practice,serum RANTES and MIF levels can be determined to predict the risk of cognitive dysfunction for early intervention and treatment.