New treatments for chronic hepatitis C / 대한간학회지
The Korean Journal of Hepatology
;
: 263-277, 2010.
Article
Dans Anglais
| WPRIM
| ID: wpr-103213
ABSTRACT
Treatments for chronic hepatitis C has evolved significantly in the past 15 years. The standard of care (SOC) is peginterferon alfa-2a/-2b with ribavirin for 48 weeks or 24 weeks in patients infected with HCV genotype 1 or 2/3, respectively. The treatment duration can be individualized based on the baseline viral load and the speed of the virologic response during treatment. However, current therapies are associated with side effects, complications, and poor patient tolerability. Therefore, there is an urgent need to identify better strategies for treating this disease. An improved sustained virologic response (SVR) can be achieved with new HCV-specific inhibitors against NS3/4A and NS5B polymerases. Recent trials have found SVR rates in patients with HCV genotype 1 infection of 61~68% and 67~75% for combining the SOC with the protease inhibitors telaprevir and boceprevir, respectively. Several new HCV-specific inhibitors such as protease inhibitors and nucleoside and non-nucleoside polymerase inhibitors as well as non-HCV-specific compounds with anti-HCV activity are currently in clinical evaluation. In this review we discuss these new treatments for chronic hepatitis C.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Antiviraux
/
Inhibiteurs de protéases
/
DNA-directed RNA polymerases
/
Interférons
/
Protéines virales non structurales
/
Hépatite C chronique
/
Pénétration virale
/
Nucléotides
Limites du sujet:
Humains
langue:
Anglais
Texte intégral:
The Korean Journal of Hepatology
Année:
2010
Type:
Article
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