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Modified Number of Extranodal Involved Sites as a Prognosticator in R-CHOP-Treated Patients with Disseminated Diffuse Large B-Cell Lymphoma
The Korean Journal of Internal Medicine ; : 301-308, 2010.
Article Dans Anglais | WPRIM | ID: wpr-103226
ABSTRACT
BACKGROUND/

AIMS:

Rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone chemotherapy (R-CHOP) has improved survival in patients with diffuse large B-cell lymphoma (DLBCL) and weakened the prognostic power of the international prognostic index (IPI). We evaluated the efficacy of the IPI and revised IPI (R-IPI) in patients with DLBCL who were treated with R-CHOP, focusing on extranodal site number (ENS) because extranodal involvement occurs frequently in Koreans.

METHODS:

A total of 126 R-CHOP-treated patients with stage III/IV DLBCL were analyzed. We performed a retrospective analysis of the clinicopathologic factors and verified the predictive power of the standard IPI and R-IPI. Various numbers of extranodal sites were analyzed for further stratification, and we set the extranodal site-modified IPI (E-IPI) as the IPI when the number of extranodal sites was stratified as or = 3.

RESULTS:

A univariate analysis showed that ENS was associated with complete response (CR, p = 0.04), event-free survival (EFS, p = 0.01), and overall survival (OS, p or = 3. A multivariate analysis revealed that an ENS > or = 3 remained associated with EFS (p or = 3, rather than the original or = 2, was the most significant prognostic factor for EFS and OS. All three indices were predictive, but only the E-IPI identified the high-risk group of R-CHOP-treated Korean patients with disseminated DLBCL.
Sujets)

Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Pronostic / Vincristine / Prednisone / Protocoles de polychimiothérapie antinéoplasique / Doxorubicine / Études rétrospectives / Lymphome B diffus à grandes cellules / Cyclophosphamide / Corée / Anticorps monoclonaux Type d'étude: Étude observationnelle / Étude pronostique Limites du sujet: Adolescent / Adulte / Adulte très âgé / Aged80 / Femelle / Humains / Mâle Pays comme sujet: Asie langue: Anglais Texte intégral: The Korean Journal of Internal Medicine Année: 2010 Type: Article

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Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Pronostic / Vincristine / Prednisone / Protocoles de polychimiothérapie antinéoplasique / Doxorubicine / Études rétrospectives / Lymphome B diffus à grandes cellules / Cyclophosphamide / Corée / Anticorps monoclonaux Type d'étude: Étude observationnelle / Étude pronostique Limites du sujet: Adolescent / Adulte / Adulte très âgé / Aged80 / Femelle / Humains / Mâle Pays comme sujet: Asie langue: Anglais Texte intégral: The Korean Journal of Internal Medicine Année: 2010 Type: Article