Olfaction and Neurodegenerative Disease / 한양의대학술지
Hanyang Medical Reviews
;
: 116-119, 2014.
Article
Dans Anglais
| WPRIM
| ID: wpr-103510
ABSTRACT
Olfactory dysfunction is an early and common symptom of many neurodegenerative diseases, particularly of Parkinson's disease, Alzheimer's disease, and mild cognitive impairment that heralds progression to dementia. Olfactory impairment is known to be related to several pathologic changes including the deposition of alpha-synuclein, hyperphosphorylated tau protein, neurofilament protein, Lewy bodies and neuritis inducing a complex cascade of molecular processes such as oxidative stress, neuroinflammation, and cytosolic disruption of cellular processes leading to cell death. The areas mainly showing these pathologic changes are the olfactory epithelium, olfactory bulb and tract, primary olfactory cortices, and their secondary target areas. Since early loss of olfactory function is common among several common neurodegenerative disorders, recent investigations have focused on its utility as a biomarker for early diagnosis and progression. Olfactory impairment appears to be an important sign for early detection, a useful biomarker for disease progression and a useful differentiator between neurological disorders.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Bulbe olfactif
/
Maladie de Parkinson
/
Odorat
/
Marqueurs biologiques
/
Muqueuse olfactive
/
Corps de Lewy
/
Mort cellulaire
/
Protéines tau
/
Stress oxydatif
/
Évolution de la maladie
Type d'étude:
Etude diagnostique
/
Étude de dépistage
langue:
Anglais
Texte intégral:
Hanyang Medical Reviews
Année:
2014
Type:
Article
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