IL-33 Priming Enhances Peritoneal Macrophage Activity in Response to Candida albicans
Immune Network
;
: 201-206, 2014.
Article
Dans Anglais
| WPRIM
| ID: wpr-103516
ABSTRACT
IL-33 is a member of the IL-1 cytokine family and plays a role in the host defense against bacteria, viruses, and fungi. In this study, we investigated the function of IL-33 and its receptor in in vitro macrophage responses to Candida albicans. Our results demonstrate that pre-sensitization of isolated peritoneal macrophages with IL-33 enhanced their pro-inflammatory cytokine production and phagocytic activity in response to C. albicans. These macrophage activities were entirely dependent on the ST2-MyD88 signaling pathway. In addition, pre-sensitization with IL-33 also increased ROS production and the subsequent killing ability of macrophages following C. albicans challenge. These results indicate that IL-33 may increase anti-fungal activity against Candida through macrophage-mediated resistance mechanisms.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Phagocytose
/
Bactéries
/
Candida
/
Candida albicans
/
Interleukine-1
/
Macrophages péritonéaux
/
Champignons
/
Homicide
/
Macrophages
Limites du sujet:
Humains
langue:
Anglais
Texte intégral:
Immune Network
Année:
2014
Type:
Article
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