Meta analysis of associations between single-nucleotide polymorphisms of rs4977574/rs1537378 in ANRIL gene and risk of ischemic stroke / 中华神经医学杂志

ABSTRACT

Objective:To study the associations between single-nucleotide polymorphisms (SNPs) of rs4977574/rs1537378 in ANRIL gene and risk of ischemic stroke. Methods:PubMed, Embase, The Cochrane Library, and CNKI, Wanfang, and VIP Data were searched from inception to September 2020 to collect literatures about randomized controlled trials on associations between SNPs of rs4977574/rs1537378 in ANRIL gene and risk of ischemic stroke. According to inclusion and exclusion criteria, the literatures were selected and the data were extracted; Stata15.1 software was used for Meta analysis of the literatures. Results:About the associations between rs4977574 polymorphism of ANRIL gene and risk of ischemic stroke, a total of 7 articles were chosen, including 12 553 patients in the case group and 15 547 patients in the control group; about the associations between rs1537378 polymorphism of ANRIL gene and risk of ischemic stroke, a total of 6 articles were chosen, including 6166 patients in case group and 6129 patients in control group. The results of Meta analysis indicated that rs4977574 polymorphism had a significant association with ischemic stroke susceptibility under 5 genetic models: allele model [G vs. A]: OR=1.110, 95%CI: 1.020-1.210, P=0.010; dominance model ([GG+GA] v s. AA): OR=1.170, 95%CI: 1.070-1.280, P=0.001; recessive model (GG vs. [GA+AA]): OR=1.160, 95%CI: 1.050-1.280, P=0.020; homozygote model (GG vs. AA): OR=1.260, 95%CI: 1.130-1.420, P=0.000; heterozygote model (GA vs. AA): OR=1.130, 95%CI: 1.030-1.240, P=0.010. The rs1537378 polymorphism was associated with reduced risk of ischemic stroke under 5 genetic models: allele model (T vs. C): OR=0.800, 95%CI: 0.700-0.920, P=0.001; dominance model ([TT+TC] vs. CC): OR=0.790, 95%CI: 0.680-0.920, P=0.002; recessive model (TT vs. [TC+CC]): OR=0.830, 95%CI: 0.740-0.930, P=0.001; homozygote model (TT vs. CC): OR=0.780, 95%CI: 0.690-0.880, P=0.000; heterozygote model (TC vs. CC): OR=0.870, 95%CI: 0.810-0.940, P=0.001. Conclusions:The rs4977574 polymorphism in ANRIL gene is a susceptibility factor for ischemic stroke, and allele G of this locus can significantly increase the risk of ischemic stroke. The rs1537378 polymorphism in ANRIL gene is a protective factor for ischemic stroke, and carrying this allele T can reduce the risk of ischemic stroke.