Association between serum homocysteine,white matter hyperintensity and cerebral microbleeds / 中风与神经疾病杂志

ABSTRACT

@#Objective　To analyze the association between serum homocysteine (Hcy),white matter hyperintensity (WMH) and cerebral microbleeds (CMBs).Methods　309 patients were divided into CMBs group (n=116) and control group (n=193),lobar CMBs group (n=90) and deep CMBs group (n=26),minor CMBs group (n=78) and major CMBs group (n=38),low-level Hcy group (n=158) and high level Hcy group (n=151) according to the quantity and site of CMBs and the median levels of Hcy.Results　The levels of Hcy,glucose,creatinine,the total score of Fazekas scale,systolic pressure and pulse pressure difference were higher in CMBs group than control group (P<0.05);Male,systolic pressure and the total score of Fazekas scale were independent risk factors of CMBs by Logical regression (P<0.05).The scores of Fazekas scale were higher in lobar CMBs group than deep CMBs group (P<0.05);Serum Hcy,the scores of Fazekas scale were related to quantity of CMBs (P<0.05).Conclusions　The serum Hcy was partcipated in the process of CMBS.The severity of WMH was correlation with lobar CMBs may play a prediction role in CMBs.