The mechanism of olfactory impairment in MPTP-induced mouse model of Parkinson’s disease / 中风与神经疾病杂志

ABSTRACT

@#Objective　To investigate the mechanism of olfactory impairment in 1-methyl-4-phenyl-1,2,3,6 tetrahydropyridine (MPTP)-treated mice.Methods　Mice were treated with MPTP,the olfactory changes and their related mechanism in MPTP-treated mice were observed by behavioral,immunohistochemical and western blot methods.Results　The results from praxiology experiment showed that the olfactory function of MPTP-treated mice was decreased,while the results from related immunohistochemistry and western blot showed that the number of dopaminergic neuron in the olfactory bulb of MPTP-treated mice was increased.Conclusion　The olfactory dysfunction in MPTP-treated mice was associated with an increase in the number of olfactory bulb DA neurons.