Effect of total burden of cerebral small vessel disease on the long-term outcome in patients with large artery atherosclerosis cerebral infarction / 中风与神经疾病杂志

ABSTRACT

@#Objective　To explore the relationship between the total burden of cerebral small vessel disease (CSVD) and the long-term outcome in patients with large artery atherosclerosis (LAA) cerebral infarction.Methods　Patients with LAA cerebral infarction who were hospitalized from June 2016 to January 2018 were retrospectively analyzed.The total burden of CSVD was evaluated according to MRI findings,the total score was 0~4.The severity of the disease was assessed by the National Institutes of Health Stroke Scale (NIHSS).The modified Rankin scale was used to evaluate the prognosis of patients at 90 days and one-year after the onset.The mRS score 0~2 was defined as good prognosis and>2 was defined as poor prognosis.Results　At 90 days after onset,72 patients had good prognosis and 60 patients had poor prognosis.At one-year followed up,88 patients had good prognosis and 60 patients had poor prognosis.At baseline,63 were in the CSVD 0~1 group and 85 were in the CSVD 2~4 group.There were significant differences in the age,proportion of hypertension,NIHSS score and mRS score at 90 days and one-year after the onset between the 2 groups(P<0.05).It was found that the total burden of CSVD was an independent risk factor for poor prognosis of long-term neurological function in patients with LAA cerebral infarction at 90 days and one-year after onset.Conclusions　The total burden of CSVD was associated with the long-term outcome in patients with LAA cerebral infarction.