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Inhibitory Effects of Yuzu and Its Components on Human Platelet Aggregation
Biomolecules & Therapeutics ; : 149-155, 2015.
Article Dans Anglais | WPRIM | ID: wpr-104380
ABSTRACT
Our previous study demonstrated that yuzu has an anti-platelet effect in rat blood. In the present study, we examined whether the anti-platelet effect of yuzu can be extended to human blood by investigating its ability to inhibit aggregations induced by various agonists in human platelet rich plasma (PRP). This study also investigated the underlying mechanism of yuzu focusing on ADP granule secretion, TXB2 formations, and PLCgamma/Akt signaling. The results from this study showed that ethanolic yuzu extract (YE), and its components, hesperidin and naringin, inhibited human platelet aggregation in a concentration-dependent manner. YE, hesperidin and naringin also inhibited TXB2 formation and ADP release. The phosphorylation of PLCgamma and Akt was significantly inhibited by YE, heperidin and naringin. Furthermore, we demonstrated that YE, heperidin and naringin has anti-platelet effects in rat ex vivo studies, and lower side effects in mice tail bleeding time studies. The results from this study suggest that YE, hesperidin and naringin can inhibit human platelet aggregation, at least partly through the inhibition of PLCgamma and Akt, leading to a decrease in TXB2 formation and granule secretion.
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Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Phosphorylation / Queue / Temps de saignement / Plaquettes / ADP / Agrégation plaquettaire / Éthanol / Plasma riche en plaquettes / Hespéridine Limites du sujet: Animaux / Humains langue: Anglais Texte intégral: Biomolecules & Therapeutics Année: 2015 Type: Article

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Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Phosphorylation / Queue / Temps de saignement / Plaquettes / ADP / Agrégation plaquettaire / Éthanol / Plasma riche en plaquettes / Hespéridine Limites du sujet: Animaux / Humains langue: Anglais Texte intégral: Biomolecules & Therapeutics Année: 2015 Type: Article