Perspectives on molecular diagnosis and targeted therapy for complex vascular malformations in pediatrics / 中华预防医学杂志
Chinese Journal of Preventive Medicine
; (12): 1481-1488, 2023.
Article
de Zh
| WPRIM
| ID: wpr-1045894
Bibliothèque responsable:
WPRO
ABSTRACT
Vascular malformations are due to abnormal development of blood and/or lymphatic vessels during embryonic life without endothelial cell proliferation. Most of the previous treatments were symptomatic methods as surgery and sclerotherapy because the pathogenic mechanism was not clearly understood. With advances in molecular biology, the pathogenesis of vascular malformations is thought to be related to inherited and/or somatic mutations that eventually activate the PI3K/ATK/mTOR, Ras/Raf/MEK/ERK pathways. Also, related studies have promoted the use of targeted inhibitors. This article provides a review of current causative genes and targeted drugs for pediatric vascular malformations, aiming to provide a basis for promoting accurate molecular diagnosis and precision targeted therapy for these diseases.
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Prolifération cellulaire
/
Anomalies vasculaires
Limites du sujet:
Child
/
Humans
langue:
Zh
Texte intégral:
Chinese Journal of Preventive Medicine
Année:
2023
Type:
Article