Comparison of Plasma Concentrations of Posaconazole with the Oral Suspension and Tablet in Korean Patients with Hematologic Malignancies / 감염과화학요법
Infection and Chemotherapy
;
: 135-139, 2017.
Article
Dans Anglais
| WPRIM
| ID: wpr-105544
ABSTRACT
The posaconazole tablet formulation was developed to have improved bioavailability compared to the oral suspension. Here, we compared posaconazole plasma concentration (PPC) with the posaconazole oral suspension versus the tablet in Korean patients undergoing remission induction chemotherapy for hematologic malignancies. PPC was measured at 3, 8, and 15 days of treatment with the oral suspension (174 patients) or the tablet (40 patients). At all time-points, mean PPC was significantly higher with the tablet compared to the oral suspension. Our findings suggest that posaconazole tablets generate an optimal PPC earlier and in more patients than the oral suspension among Korean patients.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Plasma sanguin
/
Comprimés
/
Induction de rémission
/
Biodisponibilité
/
Tumeurs hématologiques
/
Formes posologiques
/
Traitement médicamenteux
/
Antifongiques
Limites du sujet:
Humains
langue:
Anglais
Texte intégral:
Infection and Chemotherapy
Année:
2017
Type:
Article
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