Urinary 5-hydroxyindoleacetic acid (5-HIAA) excretion before and during cisplatin chemotherapy in patients with intrathoracic malignancy / 결핵
Tuberculosis and Respiratory Diseases
;
: 811-816, 1999.
Article
Dans Coréen
| WPRIM
| ID: wpr-105662
ABSTRACT
BACKGROUND:
Nausea and vomiting associated with chemotherapy are common side effects which remain difficult to control. Acute phase nausea and vomiting (0-24 hours after induction of chemotherapy) parallels plasma serotonin release, which explains the effectiveness of 5-HT3 receptor antagonists. Serotonin released from gastrointestinal enterochromaffin cells may mediate chemotherapy-induced emesis. In this study, we analyzed urinary excretion of 5-HIAA, the main metabolite of serotonin.METHODS:
Eight men and four women were studied in their cisplatin chemotherapy cycle. Urinary 5-hydroxyindoleacetic aicd (HIAA) levels were determined before and during a 24-hour period under ondansetron prophylaxis.RESULTS:
Urinary 5-HIAA excretion for a 24-hour period was increased in all patients after induction of cisplatin (P=0.002).CONCLUSION:
Cisplatin chemotherapy is associated with serotonin release in the acute phase. Our finding provides evidence for a relationship between emesis and serotonin following cisplatin chemotherapy.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Plasma sanguin
/
Vomissement
/
Sérotonine
/
Cisplatine
/
Ondansétron
/
Récepteurs sérotoninergiques 5-HT3
/
Traitement médicamenteux
/
Cellules entérochromaffines
/
Acide 5-hydroxy-indole-3-acétique
/
Nausée
Limites du sujet:
Femelle
/
Humains
/
Mâle
langue:
Coréen
Texte intégral:
Tuberculosis and Respiratory Diseases
Année:
1999
Type:
Article
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