Urokinase, urokinase receptor, and plasminogen activator inhibitor-1 expression on podocytes in immunoglobulin A glomerulonephritis
The Korean Journal of Internal Medicine
;
: 176-182, 2014.
Article
Dans Anglais
| WPRIM
| ID: wpr-105995
ABSTRACT
BACKGROUND/AIMS:
The purpose of this study was to investigate the expression of urokinase-type plasminogen activator (uPA), uPA receptor (uPAR), and plasminogen activator inhibitor (PAI)-1 on podocytes in immunoglobulin A (IgA) glomerulonephritis (GN).METHODS:
Renal biopsy specimens from 52 IgA GN patients were deparaffinized and subjected to immunohistochemical staining for uPA, PAI-1, and uPAR. The biopsies were classified into three groups according to the expression of uPA and uPAR on podocytes uPA, uPAR, and a negative group. The prevalences of the variables of the Oxford classification for IgA GN were compared among the groups.RESULTS:
On podocytes, uPA was positive in 11 cases and uPAR was positive in 38 cases; by contrast, PAI-1 was negative in all cases. Expression of both uPA and uPAR on podocytes was less frequently accompanied by tubulointerstitial fibrosis.CONCLUSIONS:
Our results suggest a possible protective effect of podocyte uPA/uPAR expression against interstitial fibrosis.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Atrophie
/
Biopsie
/
Fibrose
/
Immunohistochimie
/
Activateur du plasminogène de type urokinase
/
Marqueurs biologiques
/
Inhibiteur-1 d'activateur du plasminogène
/
Podocytes
/
Récepteurs à l'activateur du plasminogène de type urokinase
/
Glomérulonéphrite à dépôts d'IgA
Limites du sujet:
Adolescent
/
Adulte
/
Adulte très âgé
/
Femelle
/
Humains
/
Mâle
langue:
Anglais
Texte intégral:
The Korean Journal of Internal Medicine
Année:
2014
Type:
Article
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