Near-tetraploidy Acute Myeloid Leukemia with RUNX1-RUNX1T1 Rearrangement Due to Cryptic t(8;21) / 대한진단검사의학회지
The Korean Journal of Laboratory Medicine
;
: 510-514, 2009.
Article
Dans Coréen
| WPRIM
| ID: wpr-106766
ABSTRACT
Tetraploidy or near-tetraploidy is a rare cytogenetic abnormality found in AML, and is divided into primary and secondary forms. The secondary tetraploidy or near-tetraploidy found in AML is known to be specifically associated with t(8;21). In this case report, FISH analysis detected RUNX1-RUNX1T1 gene rearrangement in the absence of cytogenetic abnormality of t(8;21), which suggests the presence of unvailed t(8;21). This is the first case report of tetraploidy or near-tetraploidy AML with cryptic RUNX1/RUNX1T1 in Korea. Although the prognosis of tetraploidy or near- tetraploidy with t(8;21) is known to be poor, this patient shows a relatively good clinical course compared to other reported cases.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Polyploïdie
/
Facteurs de transcription
/
Translocation génétique
/
Chromosomes humains de la paire 8
/
Chromosomes humains de la paire 21
/
Réarrangement des gènes
/
Leucémie aigüe myéloïde
/
Protéines proto-oncogènes
/
Hybridation fluorescente in situ
/
Sous-unité alpha 2 du facteur CBF
Type d'étude:
Étude pronostique
Limites du sujet:
Adulte
/
Femelle
/
Humains
langue:
Coréen
Texte intégral:
The Korean Journal of Laboratory Medicine
Année:
2009
Type:
Article
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