Clinical Reviews of Landau-Kleffner Syndrome / 대한소아신경학회지
Journal of the Korean Child Neurology Society
;
(4): 283-289, 2003.
Article
Dans Coréen
| WPRIM
| ID: wpr-107771
ABSTRACT
PURPOSE:
We intended to describe the clinical features including characteristic etiologies, therapeutic approaches and outcomes for Landau-Kleffner syndrome(LKS).METHODS:
A retrospective chart reviews were done to reveal the clinical and electrophysiological features in 5 patients who were diagnosed as LKS and undergone extensive diagnostic work-up and various therapeutic interventions.RESULTS:
Among five LKS patients, 2 patients were males and 3 were females. All patients showed well controlled seizure outcomes but cognitive function including auditory and/or expressive aphasia were not improved in spite of using various anticonvulsants. Only two patients responded to steroid therapy but one patient showed repeated deterioration after discontinuation of the durg. Among 3 patients who were on ketogenic diet(KD), one patient showed a dramatic improvement in liguistic and cognitive functions in spite of underlying mitochondrial complex I deficiency. Multiple subpial transections (MST) were done in the other two patients because of incomplete recovery from ketogenic diet, and only one patient showed fairly successful improvement.CONCLUSION:
Cognitive regression induced by LKS could be successfully improved by various therapeutic modalities including steroid, KD and palliative MST in most patients.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Aphasie de Broca
/
Crises épileptiques
/
Études rétrospectives
/
Syndrome de Landau-Kleffner
/
Régime cétogène
/
Anticonvulsivants
Type d'étude:
Étude observationnelle
Limites du sujet:
Femelle
/
Humains
/
Mâle
langue:
Coréen
Texte intégral:
Journal of the Korean Child Neurology Society
Année:
2003
Type:
Article
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