The Effect of Angiogenin on the Development of Human Bladder Tumor / 대한비뇨기과학회지

ABSTRACT

PURPOSE: Angiogenin is involved in tumor angiogenesis, an important process for the growth and metastatic potential of solid tumors. This study was performed to evaluate the expression of angiogenin in the tumor tissues of patients with bladder tumors. The correlations of angiogenin with the tumor grade and stage were also evaluated. MATERIALS AND METHODS: The quantification for the expression of angiogenin mRNA was assessed in 106 human bladder tumor tissues, 19 normal mucosae surrounding the bladder tumor and 17 normal bladder mucosae, using a quantitative competitive polymerase chain reaction (QC-PCR). We compared the levels of angiogenin mRNA expression between the bladder tumors and the normal bladder mucosae of the controls, the bladder tumors and the normal bladder mucosae surrounding the tumors, and with regard to the tumor grades and stages. RESULTS: The levels of angiogenin mRNA expression in the bladder tumor tissues were significantly higher than in the normal bladder mucosae of the controls and the normal bladder mucosae surrounding the tumors. The angiogenin expression levels in the bladder tumors at stages T1 or above T2 were significantly higher than in the bladder tumors at stage Ta. There was no significant difference in angiogenin expressions with regard to the tumor grade. CONCLUSIONS: These data suggest that angiogenesis, mediated by angiogenin, may be involved in the tumorigenesis of the urinary bladder and the invasiveness of bladder tumors.